Evaluating the causal role of circulating inflammatory cytokines and plasma metabolites on aplastic anemia.

ABSTRACT: Aplastic anemia (AA) is a rare, potentially life-threatening bone marrow failure syndrome characterized by immune-mediated destruction of hematopoietic stem/progenitor cells. Inflammatory cytokines and plasma metabolites are key regulators of T cell activity, but their causal roles in AA pathogenesis remain to be clarified. Two-sample Mendelian randomization (MR) was used to assess causal relationships between 91 circulating inflammatory cytokines, 1400 blood metabolites, and AA risk, and further mediation Mendelian randomization was applied to explore potential mediating pathways, with inverse-variance weighted method as the primary statistical method. Interleukin-13 (IL-13) is causally associated with reduced AA risk (odds ratio = 0.8731, 95% CI = 0.7720-0.9876, P = .0308), while leukemi

SUBMITTER: Yang X 

PROVIDER: S-EPMC12708127 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature