Causal inference study on the effect of exogenous insulin on the risk of osteoarthritis.

ABSTRACT: The study explores the previously unexamined link between exogenous insulin treatment for diabetes mellitus and its potential to alter the risk of osteoarthritis (OA) using Mendelian randomization (MR) to investigate a possible causal relationship. By employing a variety of two-sample MR methodologies, including instrumental variable weighting (IVW), weighted median, MR-Egger, weighted mode, simple mode, and conducting multivariate MR (MVMR) Analysis, this research aims to assess the direct effects of exogenous insulin on OA, while also considering the mediating roles of diabetes and smoking status. Our findings through the IVW model reveal a significant causal association, indicating that exogenous insulin use is linked to a decreased risk of OA, evidenced by an odds ratio (OR) of 0.00029

SUBMITTER: Zheng J 

PROVIDER: S-EPMC12708162 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature