A two-sample Mendelian randomization analysis of the impact of GABA receptor subtypes on human height.

ABSTRACT: Gamma-aminobutyric acid (GABA) supplements are increasingly marketed for promoting growth, yet the genetic influence of GABA receptor subtypes on human height remains unexplored. This Mendelian randomization (MR) study aimed to investigate the causal relationships between genetically predicted plasma levels of 2 GABA receptor subtypes (GABRA4 and GABRB2), and height-related outcomes, including body height (BH), idiopathic short stature (ISS), and constitutional tall stature (CTS). This study employed a two-sample MR approach to assess the causal effect of GABA receptor subtypes, specifically GABRA4 and GABRB2, on height-related traits. Genetic instruments for GABRA4 and GABRB2 were obtained from the UK Biobank Pharma Proteomics Project and INTERVAL study. Outcome data, including BH, ISS, a

SUBMITTER: Chen L 

PROVIDER: S-EPMC12708188 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature