Comprehensive analysis of the biological functions and prognostic significance of GDI1 in breast cancer.

ABSTRACT:

Background

guanosine diphosphate dissociation inhibitor 1 (GDI1), a key regulator of small GTPase activity, plays a critical role in cellular signal transduction and is closely associated with the development and progression of various cancers. However, its specific functional mechanisms in breast cancer (BRCA) remain to be further elucidated.

Methods

In this study, we analyzed the differential expression of GDI1 based on the The Cancer Genome Atlas-BRCA and Gene Expression Omnibus databases, and validated its expression levels using the HPA database. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses, along with gene set enrichment analysis (GSEA), were employed to elucidate its potential biological functions. The prognostic

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12708193 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature