Thalamic metabolite changes after subthalamic nucleus deep brain stimulation in Parkinson's disease: an exploratory magnetic resonance spectroscopy study.

ABSTRACT:

Introduction

The mechanisms underlying the clinical effect of Deep Brain Stimulation (DBS) for Parkinson's disease (PD) remain debated. Proton magnetic resonance spectroscopy (¹H-MRS) provides a biochemical non-invasive in vivo insight. This article aims to increase the understanding of advanced PD pathophysiology and DBS using MRS before and after surgery.

Methods

Eleven PD patients and seven healthy controls were included. Preoperatively and approximately 7 months postoperatively, single-voxel MRS using a PRESS sequence was performed on a 1.5 T (tesla) system. Voxels were placed bilaterally in the thalamus (14 × 13 × 13 mm³) and the lentiform nucleus (15 × 13 × 12 mm³). Metabolite concentrations of total N-acetylaspartate + N-acetyl-

SUBMITTER: Goransson N 

PROVIDER: S-EPMC12708281 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature