CD47 expression in solid tumors correlates with phagocytic tumor-associated macrophage gene signature.

ABSTRACT:

Background

CD47 is a "don't eat me" signal that is overexpressed in tumors to evade phagocytosis by tumor associated macrophages (TAM). Investigational agents targeting CD47, such as magrolimab, aim to induce phagocytosis of tumor cells by TAMs. Previously, two key TAM subsets have been identified: C1QC TAMs, which display pro-phagocytic activity, and SPP1 TAMs that express pro-angiogenic markers. We characterize CD47 expression and its relationship with tumor macrophages in solid tumor samples.

Patients and methods

Resectable tumors from head and neck squamous cell carcinoma (n=36) (HNSCC), breast cancer (n=37) (BC), and colorectal cancer (n=36) (CRC) were evaluated for CD47 expression by immunohistochemistry (IHC), two multiplex immunofluorescence panels were used to chara

SUBMITTER: van Buuren N 

PROVIDER: S-EPMC12708551 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature