Unraveling the genome-wide repertoire of the novel chromosomally encoded <i>mcr-8.6</i> gene variant in <i>Klebsiella michiganensis</i> isolated from manure.

ABSTRACT: The increasing rates of colistin resistance worldwide poses a significant threat to public health. While the most commonly described variant is mcr-1, other variants such as mcr-8 have been detected, typically associated with Klebsiella pneumoniae. However, little is known about the prevalence of mcr-8 in other bacterial species and environmental reservoirs. This study aimed to characterize a novel mcr-8 subvariant identified in a Klebsiella michiganensis strain isolated from manure in Portugal, collected during an annual longitudinal survey at an Open Air laboratory, as well as to depict its genomic context and potential mobility mechanisms. The strain was subjected to phenotypic susceptibility testing, whole-genome sequencing and hybrid genome as

SUBMITTER: Riviere R 

PROVIDER: S-EPMC12708576 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature