Emergence of carbapenem-resistant <i>Salmonella</i> Typhi harboring <i>bla</i> _NDM-5 in India: genomic evidence from a multicenter study.

ABSTRACT:

Background

The rise of antimicrobial resistance (AMR) in Salmonella enterica serovar Typhi poses a serious threat to global enteric fever control. In particular, the emergence of resistance to third-generation cephalosporins and azithromycin critically undermines available treatment options. Sustained genomic surveillance of high-risk S. Typhi lineages and resistance determinants is essential for informing antibiotic policy and optimizing typhoid conjugate vaccine (TCV) introduction in endemic regions. In this study, we report a multicenter outbreak of carbapenem-resistant S. Typhi in India and investigate its genomic epidemiology, resistance mechanisms, and evolutionary origins.

Methods

A total of 31 carbapenem-resistant S. Typhi isolates collect

SUBMITTER: Thirumoorthy TP 

PROVIDER: S-EPMC12708597 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature