Adenosine in human atrial fibrillation modulates and re-distributes atria-wide dominant frequencies and directs to reentry ablation sites with improved outcome.

ABSTRACT: Understanding and therapy of persistent atrial fibrillation (AF) are suboptimal partly because the dynamics, mapping, and ablation of rotational activity that has been proposed to drive AF remain elusive. In the present work we challenge AF with Adenosine, an agonist activating the Kir3.x subfamily of inward rectifier potassium channels and known to accelerate rotors, while performing non-invasive panoramic mapping. We studied 25 persistent AF patients who underwent mapping twice at baseline (B1, B2) and again during 12 mg Adenosine (Ado) peak effect. Post-procedure, spatial distributions of dominant frequencies (DFs) and differences (ΔDFs) were analyzed. During baseline, highest 50% DF sites strongly associated with |ΔDF|≤ 0.4 Hz between B1 and B2 and most stable DFs (|ΔDF|≤ 0.1 Hz) had h

SUBMITTER: Calvo D 

PROVIDER: S-EPMC12708623 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature