Cascades of effectiveness of next-generation insecticide-treated nets against malaria, from entomological trials to real-life conditions.

ABSTRACT: As insecticide resistance spreads in Africa, next-generation insecticide-treated nets (ITNs) are increasingly being deployed to protect vulnerable populations against malaria. While these nets provide greater entomological efficacy against resistant mosquitoes, their effectiveness against malaria transmission also depends on other factors, such as durability, access, usage, and activity patterns of hosts and vectors. Here, we quantify the impact of two next-generation ITNs, namely Interceptor®G2 (chlorfenapyr-pyrethroid) and Olyset® Plus (piperonyl butoxide-pyrethroid), in a cascade from entomological efficacy to population-level effectiveness. We use a mathematical model that we parameterize with entomological data and validate against results from randomized controlled trials. We found t

SUBMITTER: Champagne C 

PROVIDER: S-EPMC12708653 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature