Association between metabolic syndrome, diabetes mellitus, inflammation and cognitive dysfunctions in schizophrenia: a cross-sectional analysis.

ABSTRACT: Metabolic syndrome (MetS) and diabetes mellitus (DM) are frequent in schizophrenia (SCZ) and have been linked to cognitive impairment and low-grade inflammation. In this cross-sectional study of adults with DSM-5 SCZ (N = 218; SCZ = 103, SCZ+MetS = 62, SCZ + DM = 53), we quantified interleukine-6 (IL-6) and C-Reactive Protein (CRP) and evaluated their associations with Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) cognitive domains and routine metabolic measures using multivariable models. Results revealed that SCZ + DM showed lower attention and delayed memory scores than SCZ and SCZ+MetS. No between-group differences were observed for immediate memory, visuospatial function, or language. IL-6 was highest in SCZ + DM, intermediate in SCZ + MetS, and lowest in

SUBMITTER: Kancsev A 

PROVIDER: S-EPMC12708724 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature