Altered cortical gyrification as a marker of treatment resistance in patients with first-episode psychosis.

ABSTRACT: Predicting treatment resistance from the first stage of psychosis aids in personalized treatment, promotes a better prognosis, and contributes to healthcare cost savings. Currently, no biomarker accurately predicts treatment resistance in patients with first-episode psychosis (FEP). This study aims to investigate the potential of cortical gyrification as a biomarker for predicting resistance in the first episode of schizophrenia. A cohort of 101 individuals diagnosed with FEP and an equivalent number of age- and sex-matched healthy controls (HCs) underwent T1-weighted magnetic resonance imaging scans immediately after their initial contact. Patients received treatment in a naturalistic clinical setting, and treatment resistance was assessed at the final point after a prolonged follow-up pe

SUBMITTER: Jang M 

PROVIDER: S-EPMC12708745 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature