Ecological Insights into Gut Microbiota Networks Across Cognitive States in Alzheimer's Disease.

ABSTRACT: The ecological mechanisms governing gut microbial community stability during Alzheimer's disease (AD) progression remain poorly understood. This study employed an ecological network to investigate microbial interactions and stability across cognitively normal controls (CK), individuals with mild cognitive impairment (MCI), and AD patients. We observed a stepwise decline in network complexity across groups, characterized by reduced clustering coefficients and average degree, from CK to AD. While the MCI group exhibited intermediate structural complexity, it displayed the highest vulnerability and lowest robustness, indicating a critical transitional state. Keystone taxa analysis revealed a significant shift in microbial community, with the CK network was enriched with diverse, potentially b

SUBMITTER: Xin H 

PROVIDER: S-EPMC12708776 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature