Chronic Alcohol Drinking Impairs Recognition Memory And Insulin-Associated Genes In The Medial Prefrontal Cortex.

ABSTRACT: Chronic alcohol drinking increases susceptibility to cognitive impairment; however, the underlying mechanisms remain unclear. In this study, we investigated the effects of chronic alcohol drinking on working and recognition memory in a Marchigian Sardinian alcohol-preferring (msP) rat line. Due to interest in insulin-based medications for alcohol use disorder, we examined insulin/insulin-like growth factor 1 (IGF-1) genes in the prelimbic (PL) and infralimbic (IL) medial prefrontal cortex, a region linked to alcohol dependence and cognition. Male and female msPs received access to alcohol (20% v/v) and water (H₂O) using a group-housed 2 bottle-choice drinking paradigm for several weeks, while controls received H₂O only. After five weeks, the radial arm maze and novel

SUBMITTER: Cruz B 

PROVIDER: S-EPMC12708821 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature