Integrating multi-polygenic scores for enhanced prediction of antidepressant treatment outcomes in an East Asian population.

ABSTRACT: Major Depressive Disorder (MDD) significantly impacts global public health, yet the effectiveness of antidepressant treatments varies widely across individuals. This study addresses an important gap in the literature by examining how multi-polygenic scores (PGSs) can improve predictions of selective serotonin reuptake inhibitor (SSRI) treatment outcomes in an East Asian population-a region where pharmacogenomic studies have been limited. We analyzed two Taiwanese cohorts: the Taipei Veterans General Hospital cohort (VGHTP, N = 177) and the National Health Research Institutes cohort (NHRI, N = 245), all receiving SSRIs. PGSs for 108 traits potentially relevant to SSRI treatment outcomes were derived from large-scale genome-wide association studies using PRS-CS and PRS-CSx, incorporating dat

SUBMITTER: Lin SC 

PROVIDER: S-EPMC12708836 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature