Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis.

ABSTRACT: Hyperoside (Hyp), a naturally occurring flavonol glycoside derived from Crataegus, otherwise known as hawthorn, possesses potent antioxidant properties and has demonstrated therapeutic potential in various oxidative stress‑related diseases, including osteoporosis (OP). However, the precise molecular mechanisms underlying the anti‑osteoporotic effects of Hyp remain to be fully elucidated. The present study aimed to evaluate the therapeutic efficacy of Hyp against OP and to elucidate its underlying mechanisms. An osteoporotic mouse model was established via bilateral ovariectomy (OVX) to assess the in vivo efficacy of Hyp. Network pharmacology was employed to predict the potential therapeutic targets of Hyp in OP. In vitro experiments using bone marrow mesenchymal stem cells (B

SUBMITTER: Li L 

PROVIDER: S-EPMC12709143 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature