Dynamic shape remodeling of vesicles by internal active filaments.

ABSTRACT: To interact with their environment, living cells use active cytoskeletal forces to form dynamic membrane structures such as tubular filopodia and sheet-like lamellipodia. To understand the formation and dynamics of these structures, we perform nonequilibrium simulations of dynamically triangulated vesicles under constrained volume. We investigate vesicle shape remodeling driven by local effects of internal active filaments, as well as large-scale shape transformations resulting from volume changes controlled by the osmotic effect. We identify the morphological behavior of vesicles across varying volumes and filament properties, including concentration, mobility, stiffness, and length. Our simulations reveal dynamic, unstable vesicle structures-such as branched tubes, sheet-tubes, cup-tubes

SUBMITTER: Shiraz AK 

PROVIDER: S-EPMC12709404 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature