Predicting red blood cell transport and capillary hemodynamics in angiogenic and tumor vascular networks in silico.

ABSTRACT: Blood flow through capillary vessels in cancerous tissue plays a crucial role in disease progression and treatment. Unlike the microvasculature in healthy tissue, which is hierarchically well organized, a cancerous tissue is characterized by chaotic organization. A detailed quantification of blood cell transport and capillary hemodynamics in tumor microvasculature is lacking. Specifically, the relationship between tumor vascular geometric abnormalities, the dynamics of flowing blood cells, and the resulting blood flow anomalies at the vasculature scale is unknown. To fill this knowledge gap, we utilize a high-fidelity computational model of the flow of a deformable red blood cell (RBC) suspension through angiogenic and tumor microvasculatures in silico, built from in vivo/ex vivo images. W

SUBMITTER: Mohan A 

PROVIDER: S-EPMC12709417 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature