Spatiotemporal dynamics of local anesthetic diffusion in nerve revealed by a 2D computational model.

ABSTRACT: Despite their extensive clinical use, the intraneural pharmacokinetics of local anesthetics, including the mechanisms determining their onset and duration, remain incompletely understood, particularly under pathological conditions. We developed a detailed, spatially compartmentalized computational model of human peripheral nerve fascicles to simulate the diffusion, accumulation, and clearance kinetics of lidocaine and bupivacaine under physiological and acidic conditions. The model integrates nerve fiber architecture, extracellular fluid compartments, and capillary-mediated clearance, parameterized using experimentally validated anatomical and physicochemical data. It was implemented in Python 3.12, employing a fourth-order Runge-Kutta integrator via the SciPy library. The results revealed

SUBMITTER: Smrkolj V 

PROVIDER: S-EPMC12709419 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature