Proteomic profiling of Alzheimer's disease and Vascular dementia reveals unique underlying signatures.

ABSTRACT:

Introduction

Alzheimer's disease (AD) and vascular dementia (VaD) account for most dementia cases. AD biomarkers remain costly and invasive, and no specific biomarkers exist for VaD.

Methods

We analyzed plasma and brain proteomics in the UK Biobank (N=53,000) and ROSMAP (N=512) to identify shared and distinct proteomic signatures of AD and VaD and assess the influence of the APOE ε4 variant.

Results

We identified 55 AD-associated and 49 VaD-associated proteins, with 13 shared. AD proteins were enriched in glycosaminoglycan binding and cholesterol metabolism; VaD proteins in virus receptor activity, cytokine activity and metalloproteinases. Both showed IGF pathway dysregulation. APOE ε4 stratification revealed distinct AD proteomic signatures beyond GFAP and NeFL. Mend

SUBMITTER: Amin N 

PROVIDER: S-EPMC12709455 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature