Disrupted Brain Hierarchical Organization in Alzheimer's Disease Progression.

ABSTRACT: Alzheimer's disease (AD) arises from synergistic interactions between amyloid-β, tau, and neurodegeneration, yet it remains unclear how these mechanisms reshape the hierarchical organization of large-scale brain dynamics. Here, we quantified directed causal interactions across 134 participants spanning the AD continuum, comprising 46 amyloid-negative healthy controls (HC-), 36 amyloid-positive healthy controls (HC+), 31 amyloid-positive individuals with mild cognitive impairment (MCI+), and 21 amyloid-positive patients with AD dementia (AD+). Resting-state fMRI was modelled using generative effective connectivity, and hierarchical organization was assessed via trophic levels and directedness. Healthy older adults exhibited a canonical hierarchy in which sensorimotor and frontoparietal regi

SUBMITTER: Montana-Valverde G 

PROVIDER: S-EPMC12709456 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature