Environmental Chemicals as Modifiers of the Association between Age and Ovarian Reserve.

ABSTRACT:

Objective

To evaluate whether the well-established age-related reduction in antral follicle counts (AFC) is greater among women with higher concentrations of endocrine-disrupting chemicals.

Design

Prospective cohort study using the doubly robust (DR) learner, a flexible machine learning method that models the relationship between an exposure and outcome of interest and identifies potential modifiers of this relation.

Subjects

Seven hundred seventy-five women aged 21-46 years enrolled in The Environment and Reproductive Health (EARTH) Study at the Massachusetts General Hospital Fertility Center, Boston, USA, between 2004 and 2019.

Exposure

Age at AFC assessment calculated as the date of antral follicle scan minus the patient's birthdate, categorized into <35 yea

SUBMITTER: Naimi AI 

PROVIDER: S-EPMC12709457 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature