ImmunoNX: a robust bioinformatics workflow to support personalized neoantigen vaccine trials.

ABSTRACT: Personalized neoantigen vaccines represent a promising immunotherapy approach that harnesses tumor-specific antigens to stimulate anti-tumor immune responses. However, the design of these vaccines requires sophisticated computational workflows to predict and prioritize neoantigen candidates from patient sequencing data, coupled with rigorous review to ensure candidate quality. While numerous computational tools exist for neoantigen prediction, to our knowledge, there are no established protocols detailing the complete process from raw sequencing data through systematic candidate selection. Here, we present ImmunoNX (Immunogenomics Neoantigen eXplorer), an end-to-end protocol for neoantigen prediction and vaccine design that has supported over 185 patients across 11 clinical trials. The wor

SUBMITTER: Singhal K 

PROVIDER: S-EPMC12709488 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature