Early Mitochondrial Defects in the 5xFAD Mouse Model of Alzheimer's Disease.

ABSTRACT:

Background

Mitochondrial (MT) dysfunction is a hallmark of Alzheimer's disease (AD). Amyloid-β protein precursor and amyloid-β peptides localize to MT and lead to MT dysfunction in familial forms of AD. This dysfunction may trigger subsequent types of pathology.

Objective

To identify the MT phenotypes that occur early in order to help understand the cascade of AD pathophysiology.

Methods

The 5xFAD mouse model was used to explore the time course of MT pathologies in both sexes. Protein biomarkers for MT dynamics were measured biochemically and MT function was measured using oxygen consumption and ATP assays.

Results

We discovered progressive alterations in mitochondrial dynamics (biogenesis, fission, fusion, and mitophagy) and function (O2 consumption, ATP gener

SUBMITTER: Sharma N 

PROVIDER: S-EPMC12709524 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature