Simulating the Transmural Mechanical Response of Functionally Graded Arterial Grafts.

ABSTRACT: With coronary artery disease remaining the leading cause of mortality worldwide, the design and manufacture of clinically viable synthetic coronary artery grafts remains a fundamental healthcare challenge. It is widely accepted that vascular mimicking materials (VMMs) should emulate the heterogeneous biomechanical and biological functions of the multilayered artery wall to ensure long-term patency postimplantation. However, few VMMs can adequately meet these complex design requirements. Poly(vinyl alcohol) (PVA)/gelatin cryogels are prospective VMMs due to their combined mechanical (PVA) and biointegrative (gelatin) features, but their development thus far has been limited to homogeneous constructs. The aim of this research is to assess the mechanical response of biomimetically designed mu

SUBMITTER: Fegan KL 

PROVIDER: S-EPMC12709613 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature