Polyphenol-Mediated Antibody Functionalization of Titanium Peroxide Nanoparticles for Cancer Cell Targeting.

ABSTRACT: Cell targeting would benefit various biotechnological applications such as disease diagnosis and cancer therapy. However, efficiently functionalizing nanoparticles with targeting ligands such as antibodies remains challenging. For example, poly(acrylic acid)-modified titanium peroxide NPs (PAATiOx) have shown promising radiosensitizing effects but suffer from poor tumor accumulation due to a lack of targeting. Herein, we developed a simple, one-pot process to noncovalently graft anti-CD44 antibodies onto the surface of PAATiOx NPs using tannic acid, a polyphenol that can bind to diverse surfaces and biomolecules via multiple molecular interactions. We evaluated the cellular binding, internalization, therapeutic efficacy, and biodistribution of the targeted particles. The anti

SUBMITTER: Akasaka H 

PROVIDER: S-EPMC12709614 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature