A novel Kupffer cell-targeting nanoparticle system to Mitigate alcohol-associated liver disease.

ABSTRACT: Alcohol-associated liver disease (ALD) is a major cause of cirrhosis-related deaths worldwide. Due to its asymptomatic progression, early diagnosis and treatment are challenging, often resulting in severe complications. To address challenges associated with conventional treatments, including non-specificity and toxicity, we developed a poly lactic-co-glycolic acid nanoparticle (PLGA NP)-based drug delivery system that specifically targets Kupffer cells (KCs), which are major drivers of chronic liver disease progression. The PLGA NPs were loaded with the anti-inflammatory agent dexamethasone, and coated with carboxymethyl chitosan (CMC), a pH-responsive polymer that facilitates dexamethasone release in the acidic inflammatory environment. A semisynthetic bile acid, INT-777 was conjugated to

SUBMITTER: Unagolla JM 

PROVIDER: S-EPMC12709622 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature