Salvage Surgery Following Systemic Therapy in Initially Unresectable Non-Small Cell Lung Cancer.

ABSTRACT:

Background

This study evaluated the safety, long-term survival, and prognostic factors associated with salvage pulmonary surgery following systemic therapy for initially unresectable non-small cell lung cancer (NSCLC).

Methods

Between 2014 and 2024, this single-center retrospective review identified 32 patients (median age: 61.0 years) with NSCLC initially considered unresectable who subsequently underwent curative-intent pulmonary resection after chemotherapy, targeted therapy, and/or immunotherapy. The primary endpoint was overall survival (OS); secondary endpoints included recurrence-free survival (RFS), major morbidity (Clavien-Dindo grade ≥ IIIa), and R0 resection rate. The Kaplan-Meier method and log-rank test were employed.

Results

Reasons for unresectability a

SUBMITTER: Seto K 

PROVIDER: S-EPMC12709654 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature