Vitamin B6 promotes the activation of primordial follicles through the PI3K/Akt signaling pathway.

ABSTRACT:

Background

Vitamins, as essential trace organic compounds for the human body, are crucial substances in the maintenance of normal reproductive function. Nevertheless, the effects of vitamins on the activation of primordial follicles and the underlying mechanisms remain unclear.

Methods

We used the in vitro culture model of newborn mouse ovaries to identify the vitamins that promote primordial follicle activation and study the mechanism of vitamin B6. The mechanism of VB6 was verified by in vivo injection model of newborn mice, oral feeding of adolescent mice, and in vitro culture model of human ovarian tissue.

Results

Thiamine monochloride (VB1), riboflavin (VB2), nicotinic acid (VB3), D-pantothenic acid (VB5), pyridoxine (VB6), folic acid (VB9), vitamin B12, L-ascorb

SUBMITTER: Wen J 

PROVIDER: S-EPMC12709700 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature