Association between 25-hydroxy vitamin D levels and risk of frailty and pre-frailty in elderly adults: a systematic review and dose-response meta-analysis of epidemiologic studies with GRADE assessment.

ABSTRACT:

Background

A growing number of studies investigated vitamin D and frailty have led to conflicting results. This systematic review and meta-analysis aimed to summarize and update the current evidence surrounding the association between vitamin D and risk of frailty and pre-frailty in elderly adults.

Methods

MEDLINE (PubMed), Scopus, Institute for Scientific Information (ISI) Web of Science databases, and Google Scholar were searched for all published articles up to January 2025. All observational studies that reported odds ratios (ORs) or relative risks (RRs) with 95% confidence intervals (CIs) for the association between 25-hydroxy vitamin D (as independent variable) and frailty (as dependent variable) were included. Maximally adjusted effect sizes were pooled. Certainty of

SUBMITTER: Khakbaz M 

PROVIDER: S-EPMC12709776 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature