Redefining cardiac risk in breast radiotherapy: a substructure-based dosimetric and biomarker correlation study.

ABSTRACT:

Introduction

This study aimed to evaluate the efficacy of the mean heart dose (MHD) as a predictor of radiation exposure to cardiac substructures and its association with markers of subclinical cardiotoxicity in breast cancer (BC) patients undergoing radiotherapy (RT). Although MHD provides an overall estimate of cardiac exposure, it does not capture the heterogeneous dose distribution across critical cardiac substructures.

Materials and methods

In an ambispective study design, dosimetric parameters, including MHD and dose-volume metrics for the left anterior descending artery (LAD), left circumflex artery (LCx), and left main coronary artery (LMCA), were analyzed in a cohort of BC patients receiving adjuvant RT. Early cardiotoxicity markers, such as N-terminal pro-B-type na

SUBMITTER: Nair RP 

PROVIDER: S-EPMC12709801 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature