Age-related epidemiology and outcomes of sepsis in Japanese critical care units: a nationwide administrative claims database study.

ABSTRACT:

Background

The global rise in the elderly population presents unique challenges in intensive care, including treatment decisions and end-of-life care due to physiological, ethical, and social complexities. However, data on the very elderly remain limited, highlighting the need for real-world, large-scale studies. We aimed to characterize the age-related epidemiology and outcomes of sepsis in Japan using a nationwide administrative claims database.

Method

We conducted a retrospective cohort study using the Japanese Diagnosis Procedure Combination database for fiscal years 2010-2019. Sepsis was defined by infection-related ICD-10 codes, blood culture testing, and administration of antimicrobials within a three-day window around admission to critical care unit. Patients were st

SUBMITTER: Kobayashi H 

PROVIDER: S-EPMC12709830 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature