Design, synthesis, characterization of ferulic acid and <i>p</i>-coumaric acid amide derivatives as an antibacterial/antioxidant agent.

ABSTRACT: Ferulic acid and p-coumaric acid, cinnamic derivatives of phenolic acid, have antibacterial, prooxidant, and antioxidant effects. In this study ferulic acid and p-coumaric acid amide derivatives were investigated for their antibacterial and antioxidant properties are described in this communication. The most effective conjugates against B subtilis were 5b (IC₅₀: 215 ​± ​1.3 ​μM) and 4d (IC₅₀: 336 ​± ​2.7 ​μM) and against P. aeruginosa were 4b (IC₅₀: 365 ​± ​2.8 ​μM) and 5b (IC₅₀: 341 ​± ​3.6 ​μM), whereas the none of conjugates were more effective against E. coli than reference Kanamycin. Conjugates 5b was the most effective against B subtilis of all the synthesized conj

SUBMITTER: Halpani CG 

PROVIDER: S-EPMC12709858 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature