Establishment of a novel alloxan-induced rabbit model exhibiting unique diabetic retinal neuropathy features assessed via ERG + VEP.

ABSTRACT:

Background

Diabetic retinal neuropathy (DRN) leads to significant visual impairment; however, no existing animal model fully replicates its neural alterations, and inconsistent induction protocols with high mortality rates hinder long-term investigations.

Methods

Adult male rabbits were randomly assigned to four experimental groups, each receiving a single intravenous injection of varying doses of alloxan and one control group. The safety and efficacy of alloxan in inducing diabetes were evaluated to determine the optimal dose. At 9 weeks following injection with alloxan, retinal function was assessed using full-field electroretinography (ERG) and visual evoked potentials (VEPs). Retinal structure was examined in rabbits using spectral-domain optical coherence tomography (SD

SUBMITTER: Li X 

PROVIDER: S-EPMC12710098 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature