A disulfidptosis-related gene signature predicts prognosis and immune-metabolic landscape in multiple myeloma.

ABSTRACT: Disulfidptosis is a newly recognized cell death induced by disulphide stress under glucose deprivation. However, its clinical implications in multiple myeloma (MM) remain largely unexplored. We identified disulfidptosis-related genes via co-expression analysis and developed a risk signature through univariate Cox, least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox regression analyses. The model was internally and externally validated for overall survival prediction. Downstream analyses included functional enrichment, tumour mutation burden (TMB), tumour microenvironment (TME) characterization and immune-metabolic profiling. Preliminary in vitro validation was conducted with PLEC-knockout KMS-11 cells under glucose deprivation. A nine-gene signature was

SUBMITTER: Wang L 

PROVIDER: S-EPMC12710123 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature