Next-generation morphology, a novel multilayer morphometric digital analysis, reveals both the basic topology and new trends of myelodysplasia of peripheral blood specimens.

ABSTRACT: Traditional microscopy compromises between resolution and field of view, limiting its diagnostic sensitivity. We present here next-generation morphology (NGM), a novel five-layer analytical approach leveraging a physical solution that enables high-resolution, large-field digital imaging, data mining and analysis of blood specimens. To test NGM performance, peripheral blood smears (PBS) from 37 myelodysplastic syndrome (MDS) patients and 30 age-matched controls were analysed. PBS topology was mapped to identify regions optimal for analysis. Red blood cells (RBCs) displayed a gradient distribution with a narrow zone suitable for accurate morphological assessment. NGM facilitated direct morphometric measurements of individual red and white blood cells (RBCs and WBCs), which were correlated wi

SUBMITTER: Katz BZ 

PROVIDER: S-EPMC12710140 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature