Analysis of the TCRβ repertoire characteristics when combining radiotherapy and immunotherapy in cancer.

ABSTRACT: Cancer is a global public health concern. Radiotherapy (RT) and immunotherapy are increasingly used in cancer treatment, but the specific immune mechanisms underlying their effects remain to be elucidated. The present study analyzed publicly available datasets, in which the T-cell receptor β chain (TCRβ) repertoire in tumor-bearing mice treated with RT and immunotherapy, as well as the TCR repertoire of T cells derived from hematopoietic stem cells (HSCs) of mice exposed to radiation doses of 0, 10 and 100 mGy were comprehensively evaluated. The results of the present study indicated that the diversity of the TCRβ complementarity-determining region 3 (CDR3) in tumor-bearing mice decreased after RT, anti-cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) and anti-programmed cell death pro

SUBMITTER: Yang X 

PROVIDER: S-EPMC12710144 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature