The impact of JAK2^V617F variant allele frequency in MPN patients following PEGylated interferon alpha discontinuation.

ABSTRACT: Treatment with pegylated interferon α resulted in a molecular response in 91% of patients with an average decrease in JAK2^V61F VAF of 48.5% from baseline. In patients that discontinued treatment, the JAK2^V617F VAF at the time of treatment discontinuation was the best indicator of durable remission over the 6-month follow-up period. Created with SMART Servier Medical Art (https://smart.servier.com/).

SUBMITTER: Brown R 

PROVIDER: S-EPMC12710198 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature