Prognostic and immunological implications of sialylation-associated gene signatures in hepatocellular carcinoma.

ABSTRACT:

Objective

The absence of effective biomarkers continues to limit early diagnostic accuracy and prognostic evaluation in patients with hepatocellular carcinoma (HCC). Aberrant sialylation (SI) has been demonstrated to contribute to therapeutic resistance and tumor progression. The aim of this investigation was to identify a sialylation-related gene (SRG) signature, evaluate its prognostic significance, and investigate associated immunological characteristics in HCC.

Methods

Transcriptomic profiles and corresponding clinical data for patients with HCC were obtained from UCSC Xena, the International Cancer Genome Consortium (ICGC), and the Molecular Signatures Database (MsigDB). Differential expression analysis, Cox regression analysis modeling, and least absolute shrinkage and

SUBMITTER: Wang GQ 

PROVIDER: S-EPMC12710266 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature