Hemoglobin variability predicts mortality in acute kidney injury patients undergoing continuous renal replacement therapy: a multi-database cohort study.

ABSTRACT:

Background

Short-term hemoglobin variability (Hb-ARV) during continuous renal replacement therapy (CRRT) may reflect blood volume instability in acute kidney injury (AKI), yet its mortality implications remain unclear.

Methods

This multi-database study analyzed adult AKI patients receiving CRRT >24 h from the Medical Information Mart for Intensive Care (MIMIC)-IV, eICU Collaborative Research Database (eICU), Amsterdam University Medical Center (AmsterdamUMC) database, and Jiangsu Province Hospital (JSPH) CRRT database. Hb-ARV, quantifying hemoglobin fluctuations during CRRT, was assessed via Cox regression and restricted cubic splines for associations with in-hospital and 1-year mortality.

Results

The MIMIC-IV, eICU, AmsterdamUMC, and JSPH cohorts included 1,32

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12710270 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature