Accuracy and actionability of mold PCR on bronchoalveolar lavage fluid for diagnosis of invasive mold disease.

ABSTRACT: Bronchoalveolar lavage fluid (BAL) is commonly obtained for diagnosing invasive mold disease (IMD) in immunocompromised patients. This study investigated the accuracy, turnaround time, and clinical actionability of mold polymerase chain reaction (PCR) on BAL. All BAL tested with mold PCR and fungal culture during the study period were included in this study. The mold PCR detected Aspergillus species, Mucorales agents, Fusarium species, and Scedosporium spp./Lomentospora prolificans. Cases were classified per the EORTC/MSGERC definitions. The sensitivity, specificity, turnaround time, and actionability of the mold PCR were measured. Out of 1,958 BAL samples tested, mold PCR was positive in 160 (8.2%) and culture in 75 (3.8%). Mold PCR was most commonly positive f

SUBMITTER: Demir KK 

PROVIDER: S-EPMC12710319 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature