Baicalein Enhances Longevity and Healthspan of <i>C. elegans</i> Through the Insulin/IGF-1 Signaling Pathway.

ABSTRACT: Baicalein, a bioactive flavonoid derived from Scutellaria baicalensis, possesses notable anti-inflammatory, antioxidative, and anticancer properties. Despite its therapeutic potential, the full scope of its effects on healthspan and longevity remains unexplored. This study investigates the impact of baicalein on longevity and health-related biomarkers using the nematode Caenorhabditis elegans. Baicalein was administered to a wild-type N2 strain, seven mutant strains, and three reporter strains. Its influence on longevity, motility, lipofuscin accumulation, and oxidative stress resistance was assessed. The methodology included Kaplan-Meier survival analysis, in vivo imaging, fluorescence microscopy, and real-time PCR to evaluate RNA and protein expression. The findings indicat

SUBMITTER: Zhao C 

PROVIDER: S-EPMC12710425 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature