Prognostic Stratification of Initial Treatments for Hepatocellular Carcinoma Using a Modified Borderline Resectable Classification.

ABSTRACT:

Aim

Although Japanese expert consensus introduced the borderline resectable (BR) criteria, additional classification is considered necessary for clinical practice. This study aimed to evaluate the prognostic predictive value of the modified BR (mBR) criteria.

Methods

From 2009 to 2024, 1056 treatment-naïve patients with hepatocellular carcinoma (HCC) and Child-Pugh A were enrolled (median age: 73 years). To obtain the mBR criteria, the original BR classification was modified by separately considering patients with extrahepatic metastasis (EHM, termed "boldly BR") (n = 42) while categorizing the rest into resectable (n = 790), mBR1 (n = 95), and mBR2 (n = 129) groups. Treatments were classified as Cur (curative: surgical resection or radiofrequency ablation), NC (non-curative

SUBMITTER: Tada F 

PROVIDER: S-EPMC12710435 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature