Maternal Apocynin During Experimental Preeclampsia Prevents BBB Permeability and Increased Vascular Tone of Cerebral Arteries in Male but Not Female Rat Adult Offspring.

ABSTRACT:

Objective

We examined if exposure to experimental preeclampsia (ePE) impacts vascular permeability and reactivity of posterior cerebral arteries (PCAs) in adult offspring, and if maternal antioxidant treatment prevents these effects in adult male and female offspring.

Methods

Offspring (F1) from rats with Normal pregnancy (NormPreg_F1), ePE_F1 and ePE treated with apocynin (ePE + apo_F1) were weighed at p24, p31, p38, and p45. Maternal apocynin was administered weekly in drinking water at a dose of ∼24 mg/kg (3 mM) on gestational days 11-20. Blood-brain barrier (BBB) permeability, structure and function of PCAs were measured from male and female adult offspring (n = 8/group, 12-29 weeks). Circulating inflammatory factors were measured by multiplex array.

Results

Male

SUBMITTER: Esposito M 

PROVIDER: S-EPMC12710456 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature