Serotonin Syndrome Versus Neuroleptic Malignant Syndrome in a Pediatric Patient Receiving Fluoxetine and Haloperidol: A Case Report.

ABSTRACT: The prevalence of mental disorders in children and adolescents has increased over the years, along with a rise in the prescription of psychotropic medications in this population. Evidence and drug safety studies in children, however, remain scarce, with many treatments being prescribed off-label. Serotonin syndrome and neuroleptic malignant syndrome are both potentially life-threatening conditions associated with the use of psychotropic medications, with symptoms frequently overlapping. This case report describes a mixed presentation of serotonin syndrome and neuroleptic malignant syndrome in a 12-year-old female patient receiving combined treatment with fluoxetine and haloperidol. She presented with intermittent generalized muscle rigidity and dystonia, tremors, muscle clonus, diaphoresis

SUBMITTER: Araez PMB 

PROVIDER: S-EPMC12710490 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature