De-Saturation of Single-Atom Copper Catalysts for Accelerating Propargylic Substitution Reactions.

ABSTRACT: Rational design of proximal coordination microenvironments surrounding catalytic sites to achieve optimal reaction kinetics represents a paramount pursuit in single-atom catalysts (SACs), yet continues to pose substantial synthetic challenges. Developing innovative strategies that simultaneously stabilize low-coordinated single-metal species on solid supports, while ensuring atomic precision and high activity, remains imperative. Herein, a de-saturation strategy for SACs is demonstrated (denoted as De-sat SACs) using a top-down approach based on a KOH-mediated Joule thermal shock to obtain under-coordinated and asymmetric SACs for efficient organic synthesis. Using copper-based SACs as a proof-of-concept, the de-saturation strategy effectively converts the CuN₄ to CuN₃

SUBMITTER: Cai Q 

PROVIDER: S-EPMC12710579 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature