Estimation of receiver operating characteristic curve when case and control require different transformations for normality.

ABSTRACT: The receiver operating characteristic curve is a popular tool for evaluating the discriminative ability of a diagnostic biomarker. Parametric and nonparametric methods exist in the literature for estimation of a receiver operating characteristic curve and its associated summary measures using data usually collected from a case-control study. Since the receiver operating characteristic curve remains unchanged under a monotone transformation, the biomarker data from both cases (diseased subjects) and controls (non-diseased subjects) are often transformed based on a common Box-Cox transformation (or other appropriate transformation) prior to the application of a parametric estimation method. However, careful examination of the data often reveals that the biomarker values in the diseased and n

SUBMITTER: Cai X 

PROVIDER: S-EPMC12710658 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature