Metabolomic Signatures of Dietary Patterns and Incident Radiographic Knee Osteoarthritis: A Case-Cohort Study from Osteoarthritis Initiative.

ABSTRACT:

Objective

Dietary factors related to inflammation, obesity, and metabolism may contribute to OA development. This study examines the relationship between metabolomic signatures of dietary patterns and radiographic knee OA incidence.

Methods

This case-cohort study included 603 participants from the Osteoarthritis Initiative, comprising 237 incident radiographic knee OA cases and 366 non-cases during a 6-year followup. Plasma metabolomes were analyzed using liquid chromatography-tandem mass spectrometry. We averaged metabolite levels at baseline and year 1 as the exposure and identified incident cases with those who had a Kellgren and Lawrence grade ≥2 in follow-ups. We selected 46 metabolites significantly associated with major food groups based on previous studies. Principal

SUBMITTER: Xu S 

PROVIDER: S-EPMC12710780 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature