α-Parvin regulation of cell re-arrangement is critical for ureteric bud branching morphogenesis.

ABSTRACT: All branched tubular structures, including the kidney collecting system, are formed by branching morphogenesis, a process that includes tip branching and trunk narrowing. Tight control of cell movement and rearrangements is a prerequisite for branching morphogenesis. The role of integrin-associated adhesion proteins in coordinating actin dynamics and cell rearrangements during branching morphogenesis is poorly understood. Here we used 3D live imaging of mouse ureteric bud branching to show that α-parvin, a component of the integrin binding ILK-PINCH-Parvin (IPP) complex, regulates tip branching and tubule thinning by inhibiting excessive cell adhesion and actin polymerization. Mechanistically, α-parvin promotes actin turnover by inhibiting activation of the small GTPases RhoA and Cdc42, wh

SUBMITTER: Dong X 

PROVIDER: S-EPMC12710801 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature