Hippocampal volume moderates the association between cerebrospinal fluid growth-associated protein 43 and episodic memory performance in older adults.

ABSTRACT: This study examined the relationships between fluid and imaging biomarkers associated with memory (cerebrospinal fluid growth-associated protein 43 [CSF GAP-43] and hippocampal volume) and episodic memory performance in 586 older adults (mean age = 72.6 years, SD = 7.2) from the Alzheimer's Disease Neuroimaging Initiative who completed CSF collection, Magnetic Resonance Imaging, and neuropsychological testing. Hierarchical linear regressions assessed whether FreeSurfer-derived total hippocampal volume or hippocampal subfield volume (subiculum, presubiculum, dentate gyrus, CA1) moderated the association between GAP-43 and episodic memory performance. GAP-43 and hippocampal volume were independently associated with episodic memory performance. Greater GAP-43 was associated with lower episodi

SUBMITTER: Lee AJ 

PROVIDER: S-EPMC12710805 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature